Preheat the oven to 350°F (175°C). Lightly coat a 9x13-inch baking dish with non-stick spray or oil.
Prepare the egg noodles according to the instructions on the package. Drain thoroughly and set aside.
In a large mixing bowl, combine the cooked chicken, boiled noodles, cream of chicken soup, sour cream, milk, shredded cheddar, frozen vegetables, garlic powder, onion powder, paprika, salt, and pepper. Stir until the ingredients are evenly distributed.
Transfer the mixture into the prepared casserole dish, spreading it into an even layer.
For the topping, mix the crushed crackers with the melted butter in a small bowl. Distribute this crumb mixture evenly over the surface of the casserole.
Place the dish in the preheated oven and bake uncovered for 25 to 30 minutes, or until the casserole is bubbling and the topping is crisp and golden brown.
Allow to cool for a few minutes before serving.